Spectrum of antibiotic susceptibility pattern in extended spectrum beta lactamase (ESBL) producing Escherichia coli in case of urinary tract infection in tertiary Medical Centre.

Dr. Ashis Kumar Saha

Volume : IX, Issue : II, February - 2020

Spectrum of antibiotic susceptibility pattern in extended spectrum beta lactamase (ESBL) producing Escherichia coli in case of urinary tract infection in tertiary Medical Centre.

Dr. Ashis Kumar Saha

Abstract :

Background: In India females are most vulnerable to both community acquired and hospital acquired urinary tract infection caused by Escherichia coli. Due to improper use of antibiotics there is emergence of multidrug–resistant ESBL producing E coli as a result mortality and morbidity of the patient are increased. Aims & Objectives: Aim of this study was to show the pattern of antibiotic susceptibility and thus resistance to different types of antibiotics against ESBL producing Escherichia coli induced urinary tract infection so that proper antibiotic can be prescribed and to know the which antibiotic should be prescribed in the local geographical area to treat urinary tract infection. Materials and method: Midstream morning clean–catch urine from the patients was sent to the nearest laboratory for culture and sensitivity without delay. After culture of the organism ESBL production was detected followed by testing of antibiotic sensitivity. Results: Urine samples from 348 patients (out of total 1800 samples, 800 males and 1000 females) demonstrated highest sensitivity to carbapenam group and nitrofurantoin, moderate sensitivity to netilmicin, amikacin, piperacillin–tazobactum, polymyxin B and colistin but highly resistant to ampicillin, chloramphenicol, ticarcillin, fairly resistant to ofloxacin group of drugs except levofloxacin, 4th generation cephalosporin. Conclusion: Progressively increasing resistance to common antibiotics against ESBL producing Escherichia coli due to unnecessary, inadvertent and over the counter use of antibiotics warn the internist to use antibiotics only after getting the result of culture–sensitivity of urine from the laboratory.