Volume : VIII, Issue : X, October - 2019
Spectrum of hepatic steatosis at autopsy
Dr. Prajakta A. Gupte, Dr. Amita S. Joshi Seth
Abstract :
Objectives: Steatosis is one of the most common histologic findings in the liver at any age and it may or may not be associated with alcohol consumption. We undertook this study to assess: 1. Prevalence of fatty change, significant or otherwise, in liver, at autopsy 2. Risk factors/ causative factors/ associated lesions, if any 3. Severity of fiosis with steatosis 4. Any associated iron deposition with fatty change Methods: All liver sections from clinical autopsies (n=308) performed in the year 2011 were screened for fatty change. The cases with fatty change were selected for further analysis. Special stains for collagen (Masson Trichrome) and iron (Prussian blue reaction) were performed on the liver sections showing significant steatosis (> 10%). Fiosis was graded as pericellular fiosis (Stage 1), portal fiosis (Stage 2), idging fiosis (Stage 3) and cirrhosis (Stage 4). Clinical and autopsy case records were retrieved for analysis of risk factors, demographic and clinical data. Results: Approximately 45% of cases showed steatosis of which around 30% showed significant steatosis. Common etiologies found were alcoholism, obesity, tuberculosis, pregnancy, cardiac disorders and diabetes. Significant steatosis was also noted in the pediatric age group where cardiac disorders were the commonest cause. Fiosis and iron deposition were variable. Conclusion: Prevalence of significant hepatic steatosis in this study was 30.5%. Among adults, alcoholism was the commonest risk factor. Others were obesity, poor nourishment and diabetes. Among children, cardiac disorders were the commonest risk factor.
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DOI : 10.36106/ijsr
Cite This Article:
SPECTRUM OF HEPATIC STEATOSIS AT AUTOPSY, Dr. Prajakta A. Gupte, Dr. Amita S. Joshi Seth INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-10 | October-2019
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SPECTRUM OF HEPATIC STEATOSIS AT AUTOPSY, Dr. Prajakta A. Gupte, Dr. Amita S. Joshi Seth INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-10 | October-2019
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