Volume : V, Issue : XI, November - 2016

SPERMATOTOXIC EFFECT OF MANCOZEB IN ADULT RATS

Dr. G. Ananthan

Abstract :

 Endocrine disrupting chemicals (EDC) are an heterogeneous group of substances present in the diet and environment able to modify endocrine homeostasis, in particular steroid and thyroid hormones: therefore reproductive health and developing life stages are the most susceptible targets. Mancozeb, a fungicide of Ethylene–bis–dithiocarbamate group is a polymeric complex of 20 % Manganese with 2.5 % zinc salt. It is commonly used for foliar application and seed treatment in agriculture. ?e present study is undertaken to assess the effect of Mancozeb induced reproductive toxicity in adult albino rats. 90 days old adult male Wister rats (Rattus norvegicus) were exposed to Mancozeb at the dose of 300 mg/kg body weight, orally for 60 days. Dosages represent 1/10 LD 50 of Mancozeb, respectively. After the treatment period, animals were euthanized, testis and accessory sex organs were removed and weighed. Epididymis were quickly, encapsulated and utilized for the estimations of sperm count, motility, viability and abnormalities. Mancozeb treatment resulted in a significant decrease in body weight, the epididymal sperm count, motility and viability as compared to control animals. Withdrawal of Mancozeb treated rats restored the Organs Weight, normal sperm morphology, sperm count, motility and viability. ?e present study reveals that the effect of Mancozeb on Spermatological toxicity in the Adult Male Rats

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr.G.Ananthan, SPERMATOTOXIC EFFECT OF MANCOZEB IN ADULT RATS, International Journal of Scientific Research, Volume : 5 | Issue : 11 | November 2016

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