Volume : III, Issue : VI, June - 2014

Structurally Significant Analysis of Tuberculosis Proteins

Syeda Shaizadi Meraj. , Tanusree Chaudhuri.

Abstract :

In this paper the main focus is on the energetically significant cation-π interaction of the structurally well resolved TB proteins. TB is a disease caused by a bacterium called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine, and ain. If not treated properly, TB disease can be fatal. Cation-π interaction plays an important role in protein structure, molecular recognition and enzyme catalysis. The residues which are involved in the cation-π interaction are Lysine, Arginine and the aromatic side chains of Phenylalanine, Tyrosine, and Tryptophan. We have analyzed cation-π interaction on a data set of 12 TB proteins where the structural resolution of the protein was 3 Å and more. It was observed that there was more number of energetically significant pairs present between Arg/ Tyr compared to other pairs. Using CaPTURE program we have determined totally 57 energetically significant pairs in a data set of 12 TB proteins

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Syeda Shaizadi Meraj, Tanusree Chaudhuri / Structurally Significant Analysis of Tuberculosis Proteins / International Journal of Scientific Research, Vol.3, Issue.6 June 2014

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