Studies on serum thyroid profile in premenopausal and postmenopausal women from tertiary care hospitals of Punjab

Kuldip Singh; Amandeep Kaur; Khushpreet Kaur; Maninder Kaur

Volume : VII, Issue : I, January - 2018

Studies on serum thyroid profile in premenopausal and postmenopausal women from tertiary care hospitals of Punjab

Kuldip Singh, Amandeep Kaur, Khushpreet Kaur, Maninder Kaur

Abstract :

Background: The human life especially of women relies in a delicate balance of hormones like estrogen, progesterone, and testosterone. Women has to go through many physiological changes such as pregnancy, menopause etc for which the female hormones are one of the main responsible factors. The thyroid hormones influence the heart, ain, kidney, along with reproductive system development. Worldwide diseases of the thyroid gland disorders are among the most prevalent endocrine disorders especially in women, second on to diabetes in world wide. Menopausal age is more prone to get overt hypothyroidism. Symptoms of hypothyroidism are similar to postmenopausal complaints so can be difficult to differentiate. Thyroid stimulating hormone (TSH) is recommended as a single best screening test for vast clinical outpatients. With this perspective, present comparative cross sectional study in premenopausal and postmenopausal women on thyroid profile was undertaken. Aim: To evaluate and compare serum thyroid profile like T₃, T₄ and TSH levels in premenopausal and postmenopausal women to observe the effect of postmenopausal hormonal changes on serum T₃, T₄ and TSH levels in women. Material & Method: 40 premenopausal women of age group 15–25 years and 40 postmenopausal women of age group 50–60 years were evaluated for serum T₃, T₄ and TSH level. Results: A significant increase by 34.45% ((p<0.01)) and 16.64% (p<0.05) was observed in TSH and T₃ levels in postmenopausal women in comparison to pre menopausal women while a nominal increase by 5.78% was recorded in T₄ levels in the serum of postmenopausal women in comparison to pre menopausal women. Conclusion: Aforementioned observations in T_{3 ,}T₄ and TSH level in postmenopausal women suggested that postmenopausal women in Punjab should be monitored for serum thyroid profile for reducing the risk of thyroid dysfunction, could be responsible for the phathophysiology of various diseases. Further large scale clinical study is needed to elucidate the relationship between thyroid dysfunction and postmenopausal women