STUDY OF CARDIOVASCULAR RISK FACTORS AMONGST PERI AND POST MENOPAUSAL WOMEN AND THEIR CORRELATION WITH SERUM ESTRADIOL LEVELS

Pooja Gupta; Prachi Srivastava

Volume : V, Issue : IV, April - 2016

STUDY OF CARDIOVASCULAR RISK FACTORS AMONGST PERI AND POST MENOPAUSAL WOMEN AND THEIR CORRELATION WITH SERUM ESTRADIOL LEVELS

Pooja Gupta, Prachi Srivastava

Abstract :

Menopause is permanent cessation of menstruation beginning 12 months after final menses. Cardiovascular risk is increased in postmenopausal women attributable to decreased serum estradiol levels. This study was conducted to study cardiovascular risk factors amongst peri and post menopausal women correlating it with serum estradiol levels. 100 women included in study were divided as group I comprising of 50 perimenopausal and group II comprising of 50 postmenopausal women. Routine investigations including serum lipid profile and serum estradiol measurements were done. Prevalence of cardiovascular risk factors was higher while serum estradiol was lower in postmenopausal group .Increased serum estradiol was associated with higher serum HDL and lower serum LDL and VLDL thus reducing the risk of cardiac diseases. Thus based on these observations, it may be said that menopausal transition represents a time of substantial adverse changes in cardiovascular risk factors for women and estradiol appears to play a cardioprotective role.