Study of Clinical profile in Patients with Cutaneous Lupus Erythematosus & their Correlation between types of Lesion.

Dr. Avijit Saha

Volume : VIII, Issue : III, March - 2019

Study of Clinical profile in Patients with Cutaneous Lupus Erythematosus & their Correlation between types of Lesion.

Dr. Avijit Saha

Abstract :

Background: This study was done to find out incidences of various types of cutaneous lupus erythematosus lesions & presence or abscence of clinical findings pertaining to various organ systems of the body among them. We also studied correlation between those clinical findings with types of cutaneous lupus erythematosus. Methods:79 pts of Clinically diagnosed cases of cutaneous LE having LE specific skin lesions as classified by Gilliam�s criteria & indeterminate cases diagnosis was done by histopathology of skin lesions were included in this study after considering exclusion criteria over a period of one year. Detailed history,physical examinations, routine blood,urine investigations & histopathology of skin lesions were done as per proforma & data were analyzed with appropriate statistical tests to determine the significance and power of the study. Results: We studied 79 CLE patients (satisfying the inclusion criteria) over the entire study period of 12 months. The study population had male:female ratio of 4:75. Mean age of study population was 27.58yr. Among the 79 patients 32 patients had pure ACLE i.e.40.51%, 19 patients had SCLE i.e. 24.05%, 15 patients had pure CCLE i.e. 18.99%, 11 patients had both ACLE and CCLE i.e. 13.92% ,1 patient had Bullous LE i.e. 1.27% and 1patients had both ACLE and Bullous LE i.e. 1.27%. In our study, systemic features correlated with types of CLE. While correlating ACLE with different systemic features we found significant association with fever(p=0.022), history of seizure and psychosis(p<0.0001), palpable lymphnode and hepatosplenomegaly(p=0.0002), serositis(p=0.003) but no association was found with pallor, oral ulcer, pedal oedema and periorbital puffiness.In case of SCLE significant association was found with fever(p=0.022), pallor(p=0.022), history of psychosis(p=0.022) and palpable lymphnode(p=0.022) but no association was found with other systemic parameters.In case of CCLE significant association was found with fever(p=0.002), pallor(p=0.01) and periorbital puffiness(p=0.039) and in case of ACLE–CCLE overlap significant association was found with fever(p=0.016) and periorbital puffiness(P=0.016). Conclusion: Our study indicates that presence of fever, psychosis, history of seizure , hepatosplenomegly, lymphadenopathy in patients presenting with cutaneous lupus erythematosus should alert the physician regarding systemic involvement and thus in those situation relevant investigation should be conducted to evaluate the presence of systemic involvement