IJSR - International Journal of Scientific Research

Dr Mamta Singh; Dr Shikha Sachan

Volume : VIII, Issue : VIII, August - 2019

Study of Efficacy and Safety of Ormeloxifene in the Management of Dysfunctional Uterine Bleeding

Dr Mamta Singh, Dr Shikha Sachan

Abstract :

BACKGROUND: Dysfunctional uterine bleeding is the major presenting complain in the patients of reproductive age group. Nonsteroidal anti–inflammatory drugs, tranexamic acid, ethamsyalate and norethisterone are the primary drugs which we use to treat the DUB cases. SERM like Ormeloxifene is a safe and effective drug to treat the Dysfunctional uterine bleeding. The objective of the study is to evaluate the efficacy and safety of Ormeloxifene in cases of DUB. METHODS: We selected 34 patients of Dysfunctional uterine bleeding in the study after taking the consent. All the patients were given Tab Sevista( ormeloxifene) 60 mg biweekly for initial 3 months then they all were switched on Tab Sevista 60 mg weekly for next 3 months. All the patients were followed up for 1 year. The result and outcome were measured by reduction of menstrual blood loss in each cycle( assessed by PBAC score), rise of Hemoglobin concentration and endometrial thickness. Patients were also evaluated for the side effect and acceptability of the drug. RESULTS: At the end of study our two patients undergone for hysterectomy due to excessive menstrual blood loss and we lost follow up of two patients. Result of the study evaluated in rest 30 patients. In our study we found significant reduction of menstrual blood loss, rise of haemoglobin concentration and endometrial thickness was also found to be significantly reduced. CONCLUSION: Ormeloxifene is a safe and effective drug without any major side effect. This drug can be used in treatment of Dysfunctional uterine bleeding.