STUDY OF EXPRESSION OF KI67 AS A MARKER FOR SEVERITY OF ORAL DYSPLASIA AND ORAL SQUAMOUS CELL CARCINOMA

Dr. Manjula Choudhury; Dr. Nazbeen Sultana; Dr. Prasanta Kumar Baruah; Dr. Kalpana Sharma; Dr.Nilotpal Konwar

Volume : VIII, Issue : IV, April - 2019

STUDY OF EXPRESSION OF KI67 AS A MARKER FOR SEVERITY OF ORAL DYSPLASIA AND ORAL SQUAMOUS CELL CARCINOMA

Dr. Manjula Choudhury, Dr. Nazbeen Sultana, Dr. Prasanta Kumar Baruah, Dr. Kalpana Sharma, Dr. Nilotpal Konwar

Abstract :

Background & objectives: Oral epithelium shows transition from normal to various grades of dysplasia to Oral Squamous cell carcinoma by increased cellular proliferation. Ki67,a nuclear memane protein,is an excellent marker of cellular proliferation.The labeling index and pattern of expression of Ki67 can be used to evaluate the grading of such lesion. Methods: 15 dysplastic lesions were divided into low risk group (mild dysplasia) and High risk group (moderate and severe dysplasia). 20 cases of oral squamous cell carcinoma are divided into WDSCC (10), MDSCC (5), and PDSCC(5) Results: All the cases showed Ki67 positivity. Most of low dysplastic cases showed only basal and parabasal positivity .And most of high dysplastic lesions and OSCC showed all layer positivity. Interpretation & Conclusions: Expression of Ki67 provides objective criteria for determining the severity of dysplasia and grades of OSCC and thus can be used as an objective marker to evaluate the grading of such lesion.