Volume : V, Issue : III, March - 2016

STUDY OF HAEMATOLOGICAL PROFILE IN PATIENTS WITH GASTROINTESTINAL MALIGNANCIES

Dr. Vasuki. S. , Dr. K. Shantaraman

Abstract :

 Background: Gastrointestinal (GI) Malignancy is one of the commonest malignancies encountered in developed and developing countries. In India, gastric cancers and rectal cancers are more prevalent. In this study, analysis of haematological profile in GI malignancies was done to know the cytomorphological changes among the blood cells and to study the variation and changes in coagulation profile. Objectives: 1. To analyse the haematological profile– Complete Blood Count (CBC), Prothrombin time (PT), activated partial thromboplastin time (aPTT) among patients of gastrointestinal malignancies. 2. To study and to compare cytomorphological changes among blood cells using peripheral blood smear examination. 3. To estimate the prognosis with haematological profile apparently. Materials and Methods: A total of 25 blood samples of patients who were diagnosed of GI malignancy, were collected and sent to the laboratory with appropriate anticoagulants. Complete Blood Cell Count (CBC), Coagulation Profile (PT and aPTT) and Peripheral Smear were studied. Results: The commonest age group affected was geriatric age group (above 61 years) and males were outnumbering in this study. Among GI malignancy gastric cancer constitute for the maximum. GI malignancy had negative impact on haemoglobin profile affecting about 68% of cases. In peripheral smear study microcytic hypochromic anaemia leads the way with 68% Conclusion: Reduced red cell count and haemoglobin, increase in neutrophil count with decreased lymphocyte count, change in coagulation profile are associated with poor prognosis. Hence early screening and diagnosis, close monitoring of haematological and coagulation profile will help in reducing morbidity and mortality.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

DR. VASUKI.S., DR.K. SHANTARAMAN STUDY OF HAEMATOLOGICAL PROFILE IN PATIENTS WITH GASTROINTESTINAL MALIGNANCIES International Journal of Scientific Research, Vol : 5, Issue : 3 March 2016

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