STUDY OF INSULIN RESISTANCE AND THYROID PROFILE IN WOMEN WITH SPONTANEOUS ABORTIONS

Annapoorani R; Nagasutha D

Volume : IX, Issue : II, February - 2020

STUDY OF INSULIN RESISTANCE AND THYROID PROFILE IN WOMEN WITH SPONTANEOUS ABORTIONS

Annapoorani R, Nagasutha D

Abstract :

Thyroid dysfunction and insulin resistance are important endocrinological causes of spontaneous abortions. This study is resistancewith spontaneous abortions Thyroid dysfunction and Insulin resistance are common endocrinological causes of abortions.The present study is a case control study where 75 patients with spontaneous abortions below 20 weeks were taken as cases and 75 patients with normal on going pregnancy without previous history of miscarriage were taken as controls. Thyroid Function Tests (Free T3 ,Free T4,TSH) ,Oral Glucose Tolerance Test following 75 mg glucose load were done in cases and controls. Fasting glucose and insulin levels were measured and Insulin resistance was calculated using homeostatic model assessment method (HOMA– IR).Free T3 levels were significantly lower and TSH levels were significantly higher in study group indicating the presence of hypothyroidism in the abortus group. The HOMA–IR insulin resistance scores were apparently higher in the study group than in the controls, but it was not statistically significant.