Study of Lipid Profile and Some  Renal Parameters in Controlled and  Uncontrolled Diabetics

Dr. K. S. Motghare; C.M. IYER; N. P. SURYAWANSHI; A. R. SONARE

Volume : III, Issue : III, March - 2014

Study of Lipid Profile and Some Renal Parameters in Controlled and Uncontrolled Diabetics

Dr. K. S. Motghare, C. M. Iyer, N. P. Suryawanshi, A. R. Sonare

Abstract :

Background: Diabetes mellitus (DM) is one of the most common chronic diseases in nearly all countries, and continues to increase in numbers and significance, as changing lifestyles lead to reduced physical activity, and increased obesity. Hyperglycemia and hyperlipidaemia are known to be risk factors for the development of micoalbuminuria in patients with diabetes, which leads to progression of end stage renal disease. Therefore assessment and monitoring of blood sugar, lipid profile and microalbuminuria has become standard practice in view of early detection of diabetic nephropathy as well as predicting CVD risk in diabetic patients. Objective: To compare Lipid profile, microalbuminuria (in terms of UACR) and serum creatinine between controlled (controlled DM= FPG≤130mg/dl and/or 2hPG≤180mg/dl) and uncontrolled (uncontrolled DM=FPG>130mg/dl and/or 2hPG>180mg/dl) T2DM patients. Materials and Methods: This was a cross–sectional hospital based study with comparison groups conducted in Indira Gandhi Govt. Medical College, Nagpur during June 2013 to November 2013. Study included 25 controlled and 25 uncontrolled diabetic patients. Results: In this study we observed the higher mean values of UACR (albuminuria), serum creatinine, total cholesterol, TG, VLDL and LDL–C in uncontrolled diabetics compared to that in controlled diabetics. This indicates that glycemic control has got a strong impact on development of endothelial dysfunction, dyslipidemia and nephropathy in diabetic patients. Therefore patients should be educated about the importance of achieving a strict glycemic control along with regular monitoring for microalbuminuria and dyslipidemia so that complications can be detected much earlier and intervention can be applied at the right time.