Study of Liver Functions Test in Severe Falciparum Malaria in Northeastern Region of Rajasthan

Hazarimal Choudhary; Prema ram Choudhary

Volume : VI, Issue : IX, September - 2017

Study of Liver Functions Test in Severe Falciparum Malaria in Northeastern Region of Rajasthan

Hazarimal Choudhary, Prema Ram Choudhary

Abstract :

Background: Severe falciparum malaria with liver function abnormalities is more vulnerable to the development of dreaded complications in Northeastern state of India. Objective: Therefore present study was designed to explore the liver Functions variables in severe falciparum malaria in Northeastern region of Rajasthan. Methods: This observational study was performed at the R N T Medical College Udaipur, India. Total 60 malarial patients who tested positive for plasmodium falciparum were enrolled in present study. Severity of falciparum was diagnosed by clinical and laboratory biomarkers as given by working group of World Health Organization and subsequently all 60 patients were divided into severe malaria (Group–I) which comprised of 20 patients and simple falciparum malaria (Group–II) it include 40 patients. A comprehensive clinical history, socio–demographic information and liver function variables were examined. SPSS–16 software was used for statistical analysis. Results: Males with falciparum malaria were significantly (p<0.01) higher as compared to females and significantly (p<0.01) higher numbers of patients died in severe malaria as compared to simple falciparum malaria. The liver function variables, Aspartate amino–Transferase (AST), Alanine amino–Transferase (ALT), serum total bilirubin and blood urea were significantly (p<0.001) higher in patients with severe malaria as compared to simple falciparum malaria while random blood glucose, serum albumin and prothrombin time were significantly (p<0.001) lower in patients with severe malaria. Conclusion: It concluded that a high incidence of severe P. falciparum malaria was significantly associated with high mortality rate and declined lung functions.