Study of Microalbuminuria and Serum lipid profile in Nondiabetic Nonhypertensive subjects with Myocardial Infarction in Ajmer District

Sarla Mahawar; Deepa Thadani; Kamlesh Tanwani; GG Kaushik; Asha Makwana

Volume : V, Issue : XII, December - 2016

Study of Microalbuminuria and Serum lipid profile in Nondiabetic Nonhypertensive subjects with Myocardial Infarction in Ajmer District

Sarla Mahawar, Deepa Thadani, Kamlesh Tanwani, Gg Kaushik, Asha Makwana

Abstract :

Background : Cardiovascular disease (CVD) is fast emerging as a prominent health problem and is one of the major cause of morbidity and mortality in the developing countries. Microalbuminuria (MAU) is a common phenomenon in patients with cardiovascular disease worldwide. ?e American Diabetes Association (ADA) and the National Kidney Foundation (NKF) define microalbuminuria as an albumin⁄creatinine ratio (ACR) between 30 – 300 �g⁄mg in both men and women. Our study was aimed to find out the prevalence of microalbuminuria and the status of serum lipid profile in nondiabetic and nonhypertensive subjects with myocardial infarction & healthy controls and also to find out association of Microalbuminuria with age, weight, BMI and serum lipid profile . ?is study was limited and this topic needs to be further worked upon. Materials and methods:?e present study was conducted on 50 non diabetic non hypertensive subjects with myocardial infarction. Cases were selected from Cardiology ward of Jawahar Lal Nehru Medical College and Associated Group of Hospital, Ajmer. Age and sex matched healthy controls (n=25), (group–1) were recruited from Jawahar Lal Nehru Medical College and Associated Group of Hospital, Ajmer. Anthropometric para– meters and biochemical estimation were performed after taking approval from Ethical Committee. ?e serum total cholesterol (TC), triglyceride (TG) and HDL cholesterol (HDL–C) were determined enzymatically, while LDL cholesterol (LDL–C) was calculated using the Friedewald formula. Microalbuminuria was determined By Clinitek microalbumin test Results: In our study out of the 50 cases 64% (n=32) had microalbuminuria. ?e difference was statistically significant P <0.001. ?e Mean�SD of Age, Weight and BMI were more in microalbuminuric cases than healthy controls and were statistically significant (P<0.05). ?e mean values of serum TC, Serum TG and serum LDL–C in microalbuminuric cases compared to healthy controls were significantly (P<0.001) raised while the mean value of serum HDL–C in microalbuminuric cases compared to healthy controls was decreased significantly (P<0.001). Conclusion: ?e observations of this study has revealed that the prevalence rates of microalb–uminuria in non–diabetic non–hypertensive subjects with myocardial Infarction was 64% . ?ere was a significant increase in the levels of TC, TG and LDL cholesterol among microalb– uminuric cases. Microalbuminuria can be used as a predictor for the early detection of cardiovascular changes along with the lipid profile markers in the general population to prevent the morbidity and mortality which are associated with acute myocardial infarction