Volume : II, Issue : III, March - 2013

Study of Pregnancy Associated Polypeptide–A & B Human Chorionic Gonadotropin in Relation to The Adverse Pregnancy Outcome & Fetal Chromosomal Anomalies

Dr. Mithil Patil

Abstract :

Study of Pregnancy Associated Polypeptide–A & B – Human Chorionic Gonadotropin in relation to the adverse pregnancy outcome & fetal chromosomal anomalies .Introduction : In our prospective study , we have screened 200 pregnant women in the first trimester of pregnancy by doing B–hcg & Papp–A levels. We tried to find out what is the average serological levels of B–hcg & Papp–A in Indian Pregnant mothers in first trimester of pregnancy. We have studied the clinical outcome of pregnancy in patients having serological levels of B–Hcg & Papp–A far away from the median.Aims & Objectives :To study the variation of b–hcg & Papp–A levels in the first trimester of pregnancy & its correlation to the pregnancy outcome .To study the incidence of fetal anomalies ( chromosomal ) in view of abnormal serological levels of B–hcg & Papp–A.Material & Methods : Prospective trial has conducted at Bharati Hospital & Research Centre, Pune where 200 pregnant patients are included into the trial. Every patients included into the trial are counseled & consented to the serological evaluation in the first trimester of pregnancy. During the 11–13 weeks of pregnancy blood is collected in a vacutainer & sent for analysis at PerkinElmer Lab Chennai. Reports are generated in Multiple Of Median & their values are studied. For analysis at the PerkinElmer lab , Delfia express technology is used which assures to be a correct level.Observations : Average B–Hcg level found in the study is 1.2 MOM in 200 patients . In 2 patients B–Hcg level is found to be more than 5 MOM while in 14 patients level of B–hcg was less than 0.5 MOM.In Patients having b–hcg levels more than 5 MOM were found to have Papp–A level less than 0.5 MOM , which on further screening found to have Downs Fetus. Average Papp–A level found in the study 1.1 MOM in 200 patients we have screened. 17 patients in our study group were having Papp–A levels less than 0.5 MOM. In these patients 2 patients were having B–Hcg levels more than 5MOMs were found to have Downs Fetus on further screening , while rest of the patients have normal B–hcg levelsConclusion :B–hcg as a sole determinant of pregnancy outcome cannot be effective because variation in B–Hcg levels away from the average MOM values has not been found with significant adverse pregnancy outcome. Papp–A level , if low ie. less than 0.5 MOM has been associated with Preterm labour & increased incidence of fetal growth restrictions (associated with pre–eclampsia).

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Mithil Patil Study of Pregnancy Associated Polypeptide-A & B � Human Chorionic Gonadotropin in Relation to The Adverse Pregnancy Outcome & Fetal Chromosomal Anomalies International Journal of Scientific Research, Vol.II, Issue.III March 2013

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