STUDY OF PROGNOSTIC SIGNIFICANCE OF ESTROGEN RECEPTOR AND PROGESTERONE RECEPTOR STATUS IN PATIENTS OF MENINGIOMA

Dr. Ranjita Kumari; Dr. Rabindra Kumar Singh

Volume : IX, Issue : V, May - 2020

STUDY OF PROGNOSTIC SIGNIFICANCE OF ESTROGEN RECEPTOR AND PROGESTERONE RECEPTOR STATUS IN PATIENTS OF MENINGIOMA

Dr. Ranjita Kumari, Dr. Rabindra Kumar Singh

Abstract :

Meningiomas are important benign tumors of the central nervous system and usually originates from the dura and arise from the meningothelial cells of the arachnoid matter. This study was mainly undertaken to evaluate the progesterone receptor and estrogen receptor status in meningiomas and their histopathological and immunohistochemistry correlation. A retrospective study was undertaken among 52 cases of meningioma admitted to department of neurosurgery at RIMS, Ranchi. About 30.8% of the patients in this study belonged to less than 30 years in this study. About 59.6% of the patients in this study were females. Meningothelial meningioma was the commonest meningioma in 50% of the cases followed by Psammomatous meningioma in 21.2%. The progesterone receptor was positive in 11.5% of the cases in this study. All the cases with progesterone receptor were females in this study. About 50% of the cases with meningothelial meningioma and Psammomatous meningioma had progesterone receptors. All the cases with progesterone receptors had no first year recurrence. The estrogen receptor was positive in 5.8% of the cases in this study. About 66.7% of the cases with estrogen receptors were females and 33.3% were males. There was first year recurrence in 9.6% of the cases in this study.