STUDY OF PROTECTIVE EFFECT OF CURCUMIN ON HEAT STRESS-INDUCED HEPATIC DAMAGE IN RATS

Dr. Sudhanshu Agrawal; Dr. Raj Kumar Goel

Volume : VII, Issue : IV, April - 2018

STUDY OF PROTECTIVE EFFECT OF CURCUMIN ON HEAT STRESS-INDUCED HEPATIC DAMAGE IN RATS

Dr. Sudhanshu Agrawal, Dr. Raj Kumar Goel

Abstract :

Background: Curcumin (CM) has been reported to protect liver against toxic injury. Recently, we reported hepatotoxiceffects of moderate heat stress (HS) in male rats.Aims & Objective: Present study incorporatesCM protective effects against HS–induced rat hepatocellular damage.Materials and Methods: CM (0.5 g/kg and 2.0 g/kg) was given orally as water suspension to rats for five consecutive days. Rats were subjected to HS daily one hour after CM administration. Assessment of status of liver enzymes, morphometric and morphological parameters were done both in unstressed (US) and HS and CM plus HS rats. Results: HS Caused increased levels of liver enzymes (82.6 to 127.8%, P<0.001) and enhanced hepatic morphological and morphometric toxic paradigms compared to US rats. Treatments with CM in HS rats caused dose–dependent reversal of the enzyme levels (7.9 to 56.3%, P<0.1 to P<0.001) and improvement in liver morphology and morphometric parameters.Conclusion: CM thus, indicated the hepatoprotective effects against HS– induced liver damage.