Study of Psychopharmacological Profile of Ondansetron  A selective 5–HT3  Receptor Antagonist

Dr Arpanpriya Dhairyasheel; Dr M.M. Bhende

Volume : V, Issue : III, March - 2016

Study of Psychopharmacological Profile of Ondansetron A selective 5–HT3 Receptor Antagonist

Dr Arpanpriya Dhairyasheel, Dr M. M. Bhende

Abstract :

Since 5–HT3 antagonists have been shown to influence dopaminergically mediated behaviours originating from nucleus accumbens, so we have investigated the psychopharmacological profile of Ondansetron pertaining to its effects on behaviours dependent on functional status of the nigrostriatal dopaminergic system viz–DA agonist (apomorphine & dexamphetamine ) induced SB (stereotyped behaviour) of the oral movement variety & neuroleptic induced catalepsy in rats. Albino rats and mice of either sex, were used for the study. In our study, Ondansetron in mice did not produce motor incoordination, ataxia or muscular hypotonia neither did it inhibit the righting reflex. It did not induce catalepsy at any of the testing time intervals and did not induce stereotyped behavior in rats. Further, pretreatment with Ondansetron did not significantly influence both apomorphine & d–amphetamine induced SB in rats. Ondansetron did not induce cage climbing behaviour in mice. Further pretreatment with Ondansetron did not significantly modify apomorphine – induced cage climbing behaviour in mice. Ondansetron pretreatment did not antagonise haloperidol– induced catalepsy in rats. So, we conclude that Ondansetron does not possess post synaptic striatal D2 DA receptor blocking activity & does not influence striatal D2 dopamine receptor mediated behaviours.