Volume : V, Issue : XI, November - 2016

STUDY OF PTEN IMMUNOHISTOCHEMICAL EXPRESSION IN ENDOMETRIAL BIOPSIES FROM PATIENTS WITH ENDOMETRIAL HYPERPLASIA AND ENDOMETRIAL CARCINOMA

Uma Singh, Sabuhi Qureshi, Shivani Mishra, Prachi Srivastava, Madhumati Goel

Abstract :

 Loss of PTEN, an early event in endometrial carcinogenesis can be used as an immunohistochemical biomarker for premalignant disease. This study was done to find PTEN expression in endometrial hyperplasia and carcinoma and to study clinicopathological correlation of such cases for PTEN expression or non expression .Study included women > 40 years of age with abnormal uterine bleeding excluding women with coagulopathies, iatrogenic bleeding per vaginum, malignancy other than endometrial carcinoma and not willing to participate. Relevant data was collected. Biopsies were send for histopathology and immunohistochemistry. Out of 28 cases with endometrial hyperplasia and 1 case with endometrial carcinoma, loss of PTEN was seen in 11 cases with endometrial hyperplasia, more with atypical hyperplasia. No significant association was seen with age, parity, BMI, diabetes, hypertension, various clinical complaints, uterine size and endometrial thickness. PTEN immunohistochemistry could be used for early diagnosis of premalignant and malignant endometrial lesions

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Uma Singh, Sabuhi Qureshi, Shivani Mishra, Prachi Srivastava, Madhumati Goel, STUDY OF PTEN IMMUNOHISTOCHEMICAL EXPRESSION IN ENDOMETRIAL BIOPSIES FROM PATIENTS WITH ENDOMETRIAL HYPERPLASIA AND ENDOMETRIAL CARCINOMA, International Journal of Scientific Research, Volume : 5 | Issue : 11 | November 2016

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