Volume : V, Issue : VIII, August - 2016

STUDY OF ROLE OF PLASMAPHERESIS IN PATIENTS WITH GUILLAIN BARRE SYNDROME

Dr. Maulik Patel, Dr. K. J. Upadhyay, Dr. Sarita Parmar, Dr. Nikhil Atolia

Abstract :

 BACKGROUND : Guillain–Barre Syndrome (GBS) is an acute, frequently severe and fulminant polyradiculoneuropathy that is autoimmune in nature. We conducted study of 50 patients of GBS admitted during period of Sep–2013 to Nov–2015. METHODS : we have enrolled patients who had been diagnosed as Guillain–Barre Syndrome ,fulfil the diagnostic criteria from the National Institute of Neurological Disorders and Stroke (NINDS) 1990 (Asbury and Cornblath, 1990). all 50 patients received plasmapheresis. Plasmapheresis was done in IHBT department, CHA with Baxter plasmapheresis machine (continuous flow). Plasmapheresis cycles were done as per severity of disease and clinical condition of the patient. Most patients received 4–5 cycle of 50ml/Kg exchange was done over 8–13 days through femoral or central venous catheter. For all patients, clinical assessment was done initially at a time of admission, then at 2 weeks, 4 weeks and 8 weeks after treatment with plasmapheresis. RESULTS : Percentage of patients recover walking with aid and without aided at the end of 4 weeks after treatment with plasmapheresis were 50% and 24% respectively . At the end of 4 weeks after treatment with plasmapheresis percentage of patients being improved by one or more disability grade was 82% and the mean grade improvement was 1.14. CONCLUSION : Though this is a study of a small number of patients, overall clinical outcome improves with plasmapheresis and it is a cheaper alternative of costly immunoglobulin therapy for poor patients.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Maulik Patel, Dr. K. J. Upadhyay, Dr. Sarita Parmar, Dr. Nikhil Atolia STUDY OF ROLE OF PLASMAPHERESIS IN PATIENTS WITH GUILLAIN BARRE SYNDROME International Journal of Scientific Research,Volume : 5 | Issue : 8 |August 2016

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