Study of salivary arecoline level in areca–nut chewers

Dr Ankita Khokhar; Dr GVR Reddy; Dr Balbir Singh Deswal; Dr Shreeyam Mohapatra; Dr Sumera Saleem

Volume : VI, Issue : XII, December - 2017

Study of salivary arecoline level in areca–nut chewers

Dr Ankita Khokhar, Dr Gvr Reddy, Dr Balbir Singh Deswal, Dr Shreeyam Mohapatra, Dr Sumera Saleem

Abstract :

Introduction: Arecoline, the main areca alkaloid of the betel nut, is reported to have cytotoxic, genotoxic, and mutagenic effects in various cells. Study was undertaken with objective to assess salivary arecoline level in areca nut chewers as compared to that of nonchewers among age group of 25 to 45 years at Jaipur India

Methodology: The patients reported to the Oral Medicine and Radiology Department of Rajasthan Dental College and Hospital, Jaipur, were selected randomly for the study. The sample consisted of 100 patients among age group of 25 to 45 years of which 50 were areca nut chewers & 50 without any kind of chewing habit (areca nut/betel nut etc) formed the control group. Patient history of habits and clinical findings of subjects were recorded on a pretested, predesigned structured Performa. The quantification of salivary arecoline levels was done by using, Agilent 1200 series (HPLC system Germany) by Reversed–phase chromatography.

Results: Out of 100 patients, 71 were males and 29 were females between the age range of 25– 45 years. A Majority of chewers (82%) were males that mean age of chewers group was 34.00 years while that of control group was 32.36 years. Results of this study found significant quantitative alteration in the form of increased arecoline levels in chewers group and no arecoline level found in control group. Arecoline level was significantly more in males as compared to females and showed positive correlation with increase in age.

Conclusion. Males arecanut chewers were at greater risk of oral pathogenicity which increases with age may as indicated by salivary arecoline level.