IJSR - International Journal of Scientific Research

Dr Kulkarni Kalpana K.; Dr Bade Sarika B.

Volume : VIII, Issue : VIII, August - 2019

Study of transfusion transmitted diseases in multitransfused haemophilic patients at tertiary care centre

Dr Kulkarni Kalpana K. , Dr Bade Sarika B.

Abstract :

Background: Haemophilia is bleeding disorder. It’s of two types, Haemophilia A (factor VIII) and Haemophilia B (factor IX) deficiency. For treatment of haemophilia patients should transfused with purified factor preparation/cryoprecipitate plasma/ fresh frozen plasma/ whole blood. So, risk of acquiring transfusion transmitted infections (TTI) is higher in multi–transfused patients. Aims and Objective: To study the Seroprevalence of HBV, HCV and HIV infection in multitransfused haemophilic patients. Methods: In study 100 Haemophilic patients were screened for anti–HIV, HBsAg and anti–HCV by using 3rd generation enzyme linked immunosorbent assay (ELISA). Results: Out of 100 haemophilic patients 14 were infected with TTI, of these 14 patients, 10 received mixed transfusions, 4 received only factor concentrate in the past with P value <0.01. Seropositive was 7% for HCV, 5% for HBV and 2% for HIV. 13 patients received more than 50 transfusions. Conclusion: This study showed that HCV and HBV infections were more frequently found than HIV in multitransfused haemophilic patients