Study of Uric Acid in Patient With Acute Myocardial Infarction

DR. MUKESH N.RATHOD; DR. NEERAJ SINGH; DR SANKET A.VASAVA; DR. DIPEN R. DAMOR; DR. JAINISH MODI

Volume : III, Issue : XII, December - 2014

Study of Uric Acid in Patient With Acute Myocardial Infarction

Dr. Mukesh N. Rathod, Dr. Neeraj Singh, Dr Sanket A. Vasava, Dr. Dipen R. Damor, Dr. Jainish Modi

Abstract :

• Cardiovascular disease has been known as major health burden worldwide. Incidence of CAD is rapidly increasing in India and other developing countries. CAD is leading cause of cardiovascular mortality worldwide. • There is evidence that high uric acid level is a negative prognostic factor in patients with mild to severe heart failure. Some evidence suggest that uric acid may exert a negative effect on cardiovascular disease by stimulating inflammation, which is clearly involved in pathogenesis of cardiovascular disease. Recent study shows that there was a close co relation between serum uric acid concentration and killip classification in patients of acute myocardial infarction. AIMS AND OBJECTIVES 1) To asses serum uric acid levels in acute myocardial infarction patients 2) To study changes in serum uric acid levels over a period of 3 days, on day0-at time of admission, day 3-36 to 54 hours after collecting the first sample 3) To associate changes in serum uric with clinical prognosis MATERIALS AND METHODS We studied 100 patients of age more than 18 years who were diagnosed as ST segment elevation acute myocardial infarction (STEMI) on the basis of clinical history, examination, ECG changes, biochemical markers and admitted in ICCU in our hospital during year 2010-2012. All patients were treated with anti IHD treatment and thrombolysed with Streptokinase, if no contraindication present. Serum uric acid level of all the patients was measured on day 0 and day 3. CONCLUSION Serum uric acid level is increased in patients of acute MI. From our study, we can conclude that serum uric acid level in MI patients correlates significantly with the killip grading of the patient and it can be used as a prognostic marker in patients with acute MI.