Volume : VII, Issue : I, January - 2018

STUDY ON ANTIDEPRESSANT ACTIVITY OF TAPENTADOL

Dr. S. Vasanth, Dr. R. Sarojini

Abstract :

 

AIMS: To evaluate the antidepressant activity of tapentadol in Swiss albino mice. MATERIALS AND METHODS: Thirty ined male albino mice weighing 20–25 grams were selected from central animal house. They were divided into five groups of six animals each. The control group I received normal saline 10 ml/kg intraperitoneally, standard group II received fluoxetine (20 mg / kg, intraperitoneally) and test groups III, IV, V received tapentadol in graded doses 10mg/kg, 20g/kg and 40 mg /kg intraperitoneally. Antidepressant activity was assessed by using Forced swim test. The results were tabulated and analysed with suitable statistical method. RESULT: Tapentadol showed statistically significant antidepressant activity at all the three test doses (P< 0.05). The results were comparable to that produced by standard drug fluoxetine. CONCLUSION: Tapentadol have antidepressant activity which is comparable to fluoxetine. Further, studies are essential to prove the anti–depressant effect of Tapentadol in human.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. S.VASANTH, Dr. R.SAROJINI, STUDY ON ANTIDEPRESSANT ACTIVITY OF TAPENTADOL, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-1 | January-2018

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