Studying the effects of Intravenous Magnesium Sulfate and Fentanyl Citrate on Circulatory Changes During Anaesthesia and Surgery

Dr.Dipika Patel; Dr. Amita Jansari; Dr. Surekha Shaboo; Dr. Kuldeep Singh

Volume : V, Issue : IX, September - 2016

Studying the effects of Intravenous Magnesium Sulfate and Fentanyl Citrate on Circulatory Changes During Anaesthesia and Surgery

Dr. Dipika Patel, Dr. Amita Jansari, Dr. Surekha Shaboo, Dr. Kuldeep Singh

Abstract :

Introduction: Magnesium sulphate is a inhibitor of catecholamine from adrenergic nerve endings and adrenal medulla, calcium antagonist and a potent L–type calcium channel inhibitor which plays important role to attenuate the symapthoadrenal responses during anaesthesia and surgery. Aim: To compare the effect of intravenous magnesium sulfate with potent short acting opoid fentanyl citrate on circulatory changes and other effects during perioperative period and surgery. Material and method: 50 adult patients ranging from 18–60 years of age, ASA 1 and 2 undergoing modified radical mastectomy were selected and placed in two different groups (25 in each group). Group M received Inj. Magnesium sulfate 30 mg/kg i.v. 5 mins before induction, 20 mg/kg 5 mins before skin incision, 10 mg/kg every 30 mins till the end of surgery. Group F received Inj. Fentanyl Citrate 1.5 mcg/kg i.v. 5 min before induction ,1mcg/kg 5 min before skin incision ,0.5 mcg/kg every 30 min till the end of surgery. Changes in HR, S.B.P., , D.B.P. M.A.P. were recorded at different time interval. Result: All parameters maximum rise is immediately after intubation followed by rise lesser than the previous rise at the time of skin incision which is statistically not significant in both the groups. Rises in MAP and mean HR from pre induction value, immediately after intubation was 5.46% and 5.55% in magnesium sulphate and fentanyl citrate group respectively. Total requirement of Inj. Vecuronium is reduced by 40% in group M compared to group F. Conclusion: Magnesium sulphate and fentanyl citrate both are equally effective for attenuation of hemodynamic response to stress of surgery and anaesthesia.