Volume : IV, Issue : VI, June - 2015

SUBSTANCE P:PULPAL PAIN

Dr. Mehnaz Rajab

Abstract :

 Current evidence supports the central role of neuropeptides in the molecular mechanisms underlying dental pain. In particular, substance P, a neuropeptide produced in neuron cell bodies localised in dorsal root and trigeminal ganglia, contributes to the transmission and maintenance of noxious stimuli and inflammatory processes. The major role of substance P in the onset of dental pain and inflammation is increasingly being recognised. Well–grounded experimental and clinical observations have documented an increase in substance P concentration in patients affected by caries, pulpitis, or granulomas and in those undergoing standard orthodontic or orthodontic/dental care procedures. On this basis, SP can be considered a major mediator of neurogenic inflammation and associated hyperalgesia and represents a promising target for therapies aimed at controlling pain and minimising deleterious consequences of tissue injury

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr.Mehnaz rajab Substance P : Pulpal Pain International Journal of Scientific Research, Vol : 4, Issue : 6 June 2015

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