Volume : V, Issue : III, March - 2016

SYNTHESIS AND ANTIMICROBIA ACTIVITY OF NEW THIAZOLIDINE–4–ONE DERIVATIVES

Udaykumar Bhoi, Pramila T.

Abstract :

 Present article is sincere attempt to synthesis series of 3–(2–aminophenyl) –2– ( 4–hydroxyphenyl)–1,3–thiazolidin– 4–one derivatives were synthesized from 4–{(E)–[ (2–aminophenyl) imino] methyl} phenol, Schiff base by condensation reaction. 4–{(E)–[(2–aminophenyl)imino]methyl}phenol synthesized by using aldehydes and o–phenylenediamine and cyclization of the compound were done by thioglycolic acid. The compounds obtained were purified by column chromatography using silica gel. The chemical structures of the compounds were confirmed using IR, H1–NMR and mass spectroscopy. All the synthesized compounds were screened for their preliminary antimicrobial properties. Some of the compounds exhibited promising antimicrobial activities.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Udaykumar Bhoi, Pramila T. SYNTHESIS AND ANTIMICROBIA ACTIVITY OF NEW THIAZOLIDINE–4–ONE DERIVATIVES International Journal of Scientific Research, Vol : 5, Issue : 3 March 2016

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