Synthesis and evaluation of heterocyclic derivatives of morpholinoNacetyl indoles for central nervous system depressant activity

Bhupender Singh Rawat; Shrawan Kumar Shukla

Volume : V, Issue : IX, September - 2016

Synthesis and evaluation of heterocyclic derivatives of morpholinoNacetyl indoles for central nervous system depressant activity

Bhupender Singh Rawat, Shrawan Kumar Shukla

Abstract :

In the present work, 2–oxo–3[4`–p (subst/unsubst)–phenyl–2`–thiazolyl/oxazolyl] morpholino–N–acetyl indoles were synthesized. The different heterocyclic moieties were condensed with isatin in ethanol containing few drops of glacial acetic acid which were converted into various Thiazolyl/oxazolyl imino indoles. The imino indoles were condensed with chloro acetyl chloride in K2CO3 which were converted to N–chloro acetyl indole derivatives which on subsequent treatment with morpholino in benzene were converted to title compound. The structures of the synthesized compounds were characterized on the basis of IR and HNMR spectral data. Among all the synthesized compounds few selected compounds were screened for their CNS activity. Chlorpromazine hydrochloride is employed as a reference standard. From the results it is concluded that, synthesized compounds show more depressant activity than reference standard.