IJSR - International Journal of Scientific Research

DINESH V.BHAGAT; VIKAS V. VAIDYA

Volume : VI, Issue : XII, December - 2017

SYNTHESIS, CHARACTERIZATION & ANTIBACTERIAL STUDIES ON MIXED LIGAND Cu (II) COMPLEXES WITH POLYDENTATE LIGANDS

Dinesh V. Bhagat, Vikas V. Vaidya

Abstract :

Mixed ligand Cu (II) complexes of the type [M (Q) (L).2H₂O] have been synthesized using 8–hydroxyquinoline (HQ) as a primary ligand and N–and/or O–donar amino acids (HL) such as L–valine, L–asparagine, L–glutamine, L–arginine and L–methionine as a secondary ligands. The metal complexes have been characterized on the basis of elemental analysis, electrical conductance, room temperature, magnetic susceptibility measurements, spectral and thermal studies. The electrical conductance studies of the complexes in DMSO (dimethyl sulphoxide) in 10^–3 M concentration indicate their non–electrolytic nature. Room temperature magnetic susceptibility measurements revealed paramagnetic nature of the complexes. Electronic absorption spectra of the complexes show intra–ligand, charge transfer transition & d–d transition. The thermal analysis data of the complexes indicate the presence of crystallized water molecules. The agar cup method & tube dilution method have been used to study the antibacterial activity of the complexes against the pathogenic bacteria S.aureus, C.diphtheriae, S.typhi & E.coli. The results have been compared with those of control tetracycline, which was screened simultaneously & indicated mild antibacterial activity of the complexes.