SYNTHESIS, CHARACTERIZATION & PHARMACOLOGICAL SCREENING OF NEWLY SYNTHESIZED QUINOLINE DERIVATIVES

Piyush Yadav; Jyotsna Pandey; Braj Nandan Kishor; Smita Verma; Priya Mishra

Volume : IX, Issue : VIII, August - 2020

SYNTHESIS, CHARACTERIZATION & PHARMACOLOGICAL SCREENING OF NEWLY SYNTHESIZED QUINOLINE DERIVATIVES

Piyush Yadav, Jyotsna Pandey, Braj Nandan Kishor, Smita Verma, Priya Mishra

Abstract :

A series of novel Quinoline derivatives have been synthesized. These derivetives were prepared from the formation of intermediates 2–chloroquinoline–3 carbaldehyde and tetrazolo[1,5–a]quinoline–4–carbaldehyde and amines. The intermediate 2–chloroquinoline–3 carbaldehyde was prepared from Vilsmeier– haack reagent. The use of Vilsmeier–Haack (VH) reagent (POCl3/DMF) for the formylation of a variety of both aromatic and heteroaromatic substrates is well documented. It is now used as a powerful synthetic tool for the construction of many heterocyclic compounds. In this reaction we have formed firstly Vilsemeier–haack reagent by DMF and POCl3 added drop wise at 0–50C with continuous sterring. With the help of Vilsemeier–haack reagent and acetanilide at 90–1000C formed 2–chloroquinoline–3 carbaldehyde and then with the help of 2–chloroquinoline–3 carbaldehyde, PTSA, NaN3 and ethanol formed tetrazolo[1,5–a]quinoline–4–carbaldehyde and then with the help of tetrazolo[1,5–a]quinoline–4–carbaldehyde and different amines and solvent formed various derivatives which have significant anti–inflammatory activity. The structures of derivatives have been confirmed by the IR, H1 NMR spectral data. The compounds showed anti–inflammatory activity.