SYNTHESIS OF 6–ARYL BENZIMIDAZO[1,2–C]QUINAZOLINE DERIVATIVES AND THEIR ANTIMICROBIAL EVALUATION

C. Nisha Shri; Ajithadas Aruna; T. Vetrichelvan

Volume : IV, Issue : VIII, August - 2015

SYNTHESIS OF 6–ARYL BENZIMIDAZO[1,2–C]QUINAZOLINE DERIVATIVES AND THEIR ANTIMICROBIAL EVALUATION

C. Nisha Shri, Ajithadas Aruna, T. Vetrichelvan

Abstract :

Benzimidazo[1,2–c]quinazoline is a fused heterocyclic ring structure which is said to have many pharmacological properties. In this current study we intended to synthesis few derivatives of 6–aryl benzimidazo [1,2–c]quinazoline and study their antimicrobial property against Escherichia coli, Salmonella paratyphi, Staphylococcus aureus, and Bacillus subtilis using ciprofloxacin as antibacterial standard, and against Aspergillus niger and Candida albicans using clotrimazole as antifungal standard. The intended derivatives were synthesized by heating the substituted acid chlorides with 2–(2–aminophenyl) benzimidazole.The structures of the synthesizedBenzimidazo[1,2–c]quinazoline were established by IR and 1H–NMR analysisand studied for antimicrobial activity by well diffusion method in the agar plate.The antimicrobial effectiveness was determined by measuring the zone of inhibition around well. The synthesized compounds were effective against Candida albicans species and showed very poor activity against the other studied organisms.