Synthesis of Arylfuran Propenones and  Study of their Mosquito–Larvicidal and  Antibacterial Properties

Prakash Anil Castelino; Jagadeesh Prasad Dasappa; Prashantha Naik; Sharath Chandra K.; Vishma B. L.

Volume : III, Issue : IV, April - 2014

Synthesis of Arylfuran Propenones and Study of their Mosquito–Larvicidal and Antibacterial Properties

Prakash Anil Castelino, Jagadeesh Prasad Dasappa, Prashantha Naik, Sharath Chandra K. , Vishma B. L.

Abstract :

A series of novel arylfuranpropenones (chalcones) (4a-p), are synthesized by treating different arylfurfurals (2) with 2,3,4-trichloroacetophenone (3) in the presence of aqueous alkali and ethanol as solvent. The novel arylfuraylpropenones (4a-p) were characterized by FT-IR, 1H-NMR, 13C-NMR, Mass spectra and elemental analyses and were screened for their mosquito-larvicidal and antibacterial activities in which a few of them exhibit moderate activities. Among all the novel derivatives, the compounds (4k) and (4p) may be considered as a potential antibacterial agents as well as mosquito-larvicidal agents.