Synthesis of Dutasteride Loaded  Nanoemulsion

Nizamul H Ansari; Eram Anis; Saba Firdose; Sumbul Firdaus; Shadma Wahab; Mohammad Faiz Ahmad; Neeraj Mishra

Volume : II, Issue : XI, November - 2013

Synthesis of Dutasteride Loaded Nanoemulsion

Nizamul H Ansari, Eram Anis, Saba Firdose, Sumbul Firdaus, Shadma Wahab, Mohammad Faiz Ahmad, Neeraj Mishra

Abstract :

The effectiveness of a drug changes with size as well as molecular confirmation. The physical properties of the oil phase and the nature of the surfactant layer were found to have a considerable impact on nanoemulsion formation and stabilization. The optimization of surfactant architecture, and differential viscosity, has led to the formation of remarkably small nanoemulsions. In this work, we study emulsions consisting of water, in oil (eucalyptus oil and oleic acid in 1:1 ratio forms the oil component) and a mixture of surfactants (tween80 and ethanol). It is done by the formulation of placebo nanoemulsion. The placebo which is clear and thermodynamically stable is used for drug loading. Analysis is done by TEM.