Synthesis of Novel 1,3,4, Oxadiazole from Chloro (amino pyrazoly) ketone carbohydrazide, their Fluorescence properties and Xanthine oxidase inhibitory activity

Shailesh Prabhakar Ghag; Chitra Rajesh Kamath

Volume : VI, Issue : V, May - 2017

Synthesis of Novel 1,3,4, Oxadiazole from Chloro (amino pyrazoly) ketone carbohydrazide, their Fluorescence properties and Xanthine oxidase inhibitory activity

Shailesh Prabhakar Ghag, Chitra Rajesh Kamath

Abstract :

In order to explore high strength organic electro transporting electroluminescent (EL) materials, three new pyrazole oxadiazole compounds containing the phenyl group in the 1st position of pyrazole, methyl group at 3rd position, amino pyrazole ketone with 1,3,4 oxadiazole moiety contains various substituent in the 4th position and chloro group in the 5th position of pyrazole were synthesized. Their structures were characterized by IR, 1H NMR spectra and elemental analysis. A new method of synthesizing 1,3,4–oxadiazole compound was described showing fluorescence characteristic. The fluorescence properties were measured by fluorometry. And synthesized oxadiazole were tested for xanthine oxidase inhibitory activity against standard drug Allopurinol.