Tacrolimus versus Cyclosporine– Comparative Evaluation as First line drug in Vernal keratoconjuctivitis.

Dr Rashmi kumari; Dr Bhawesh Chandra Saha; Dr Bibhuti Prasanna Sinha; Dr Nilesh Mohan

Volume : V, Issue : XII, December - 2016

Tacrolimus versus Cyclosporine– Comparative Evaluation as First line drug in Vernal keratoconjuctivitis.

Dr Rashmi Kumari, Dr Bhawesh Chandra Saha, Dr Bibhuti Prasanna Sinha, Dr Nilesh Mohan

Abstract :

To evaluate and compare the efficacy, side effects and recurrence rate of vernal kerato conjunctivitis (VKC) with 0.03% tacrolimus and 0.05% cyclosporin,a prospective randomised double blinded comparative study was conducted at a tertiary eye center. 46 Patients of VKC between March 2015– August 2015 were randomly divided into two groups and treated for 6weeks with either Tacrolimus(0.03%) eye ointment BD or Cyclosporine (0.05%) eyedrops QID.?e main outcome measures were scoring and comparison of Total subjective symptom scores (TSSS) and Total objective ocular sign scores (TOSS) within and between the Groups at each follow up. 32 patients with comparable baseline characters were analysed. With treatment both TSSS and TOSS decreased consistently in both groups without any adverse effects but an increase in scores was noticed within two weeks after drug withdrawl.Conclusion; Both drugs are equally effective and safe in VKC but with short lasting effect