TAURINE SUPPLEMENTATION IMPROVES INSULIN SENSITIVITY AND LIPID PROFILE IN PCOS WOMEN

G.Hariprasath; Dr.S.Sakila; Dr.K.Lavanya Kumari; Dr.S.Sethupathy

Volume : VII, Issue : I, January - 2018

TAURINE SUPPLEMENTATION IMPROVES INSULIN SENSITIVITY AND LIPID PROFILE IN PCOS WOMEN

G. Hariprasath, Dr. S. Sakila, Dr. K. Lavanya Kumari, Dr. S. Sethupathy

Abstract :

Background: Polycystic Ovarian Syndrome is responsible for 75% of anovulatory infertility in women. Evidence suggests that insulin resistance (IR) and secondary hyperinsulinemia play an important role in its pathogenesis. Metformin the most extensively used insulin sensitizer in PCOS has been reported to exhibit mixed results. Hence in the present study we compared the– add on effect of taurine with metformin on insulin resistance and metabolic features in pcos women.

Design: Experimental study.

MATERIAL AND METHODS: Sixty PCOS women of 18–30 years who fulfilled the Rotterdam criteria were randomized equally into two groups and treated with metformin (1000mg/day) and combined metformin (1000mg/day) and Taurine (1000 mg/day) therapy for 3 months. Fasting Plasma glucose, insulin, HOMA IR, QUICK–I and Lipid profile, insulin indices were measured at the baseline and after 3 months of treatment in both the groups.

Results: Both groups showed significant reduction in fasting insulin levels, HOMA–IR and cholesterol levels. But greater reduction was observed in the combined treatment group than the metformin group alone. The metformin and taurine group also exhibited a significantly raised HDL and QUICK–I than the metformin group. No significant difference was observed in fasting plasma glucose levels in both the groups.

Conclusion: Supplementation of Taurine exerts beneficial effect over metformin alone on insulin resistance and metabolic features and it can be considered as a treatment option for the management of PCOS.