The association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and thyroid cancer risk

Dr. Mohamed Youssry; Prof. Dr. Faten Zahran; Prof. Dr. Mohamed Elgharib; Dr. Enas Oraby; Prof. Dr. Sahar Hamed

Volume : VIII, Issue : II, February - 2019

The association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and thyroid cancer risk

Dr. Mohamed Youssry, Prof. Dr. Faten Zahran, Prof. Dr. Mohamed Elgharib, Dr. Enas Oraby, Prof. Dr. Sahar Hamed

Abstract :

Angiotensin I–converting enzyme (ACE) gene plays an important role in the pathogenesis of cancers. The association between ACE insertion/deletion (I/D) polymorphism and the risk of various cancers has been studied. The aim of this study was to identify possible correlation between thyroid cancer and the ACE I/D gene polymorphism, to evaluate whether the ACE I/D polymorphism could be a marker for early diagnosis and prognosis. As well as we analyzed the oxidative status of TC both directly, by measuring malondialdehyde (MDA), and indirectly, by evaluating the total antioxidant capacity (TAC), these in addition to thyroid hormones level of FT4 and TSH. ACE I/D was amplified with specific primer sets recognizing genomic DNA from thyroid cancer (n=52), thyroiditis (n=56) and control (n=66) volunteers. A significant increase (P< 0.0001) in thyroid hormones as well as MDA was observed in both thyroiditis and TC group when they compared to healthy group. While TAC show a significant decrease (P< 0.0001) in both thyroiditis and TC group when they compared to healthy group. Results showed no significant association between the ACE DD genotype and the risk of thyroid cancer when compared to control group (DD vs not DD: OR = 1.3, 95% CI = 0.24– 7.07, P= 0.54). While, thyroiditis group exist a significant risk for ACE DD genotype when compared to healthy group (OR 6.000, 95% CI = 1.413– 25.481; P=0.012). We conclude that the ACE gene I/D polymorphism are not related with the TC. Thus it cannot be regarded as an early diagnostic parameter or as a risk estimate for TC predisposition. MDA may have risk estimate for TC in addition to regular hormonal measure. The risk estimate for ACE gene I/D polymorphism was documented to the thyroiditis group