Volume : VI, Issue : IX, September - 2017
The association between TNF polymorphisms and susceptibility to Rheumatoid arthritis: A meta–analysis
Dr Sandhya Manorenj, Dr Muralikrishna P. S, Dr S Sravan Kumar, Dr Navya Sagari
Abstract :
Objective: The goal of this study was to investigate whether the tumor necrosis factor– α (TNF– α) –308 G/A and –238 G/A promoter polymorphisms are associated with the risk of developing Rheumatoid arthritis (RA).
Methods: The authors conducted a comparative meta–analysis, incorporating 3131 RA patients and 3490 healthy controls from a total of 18 studies consisting of 29 separate comparisons. The tests were performed by the using fixed or random effects models.
Results: A positive association was found between TNFα–308G/A polymorphism (OR =0.845, 95%CI =0.752–0.949, P = 0.005) and TNFα –238 G/A polymorphism and RA risk by meta–analysis (OR = 0.744, 95% CI = 0.602– 0.920, P = 0.006) in the overall population. On stratification by ethnicity a significant association was found between TNFα–308G/A polymorphism and RA risk in Latin American (OR=1.578, 95%CI=1.073 – 2.320, P=0.020) and Asian (OR=0.644, 95%CI=0.501–0.828,P= 0.001) and for TNFα –238 G/A in Europeans (OR=0.595, 95%CI=0.435–0.815, P=0.001) and Latin Americans (OR=0.493, 95%CI=0.245–0.992, P=0.047).
Conclusion: Meta–analysis of available data revealed that the TNFα–308G/A polymorphisms is a susceptibility factor for developing RA in Latin Americans and Asians but not in Europeans and TNFα–238 polymorphism is susceptibility factor for RA in Latin Americans and Europeans but not in Asian population.
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DOI : 10.36106/ijsr
Cite This Article:
Dr Sandhya Manorenj, Dr Muralikrishna P.S, Dr S Sravan Kumar, Dr Navya Sagari, The association between TNF polymorphisms and susceptibility to Rheumatoid arthritis: A meta–analysis, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-9 | September-2017
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References :
Dr Sandhya Manorenj, Dr Muralikrishna P.S, Dr S Sravan Kumar, Dr Navya Sagari, The association between TNF polymorphisms and susceptibility to Rheumatoid arthritis: A meta–analysis, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-9 | September-2017
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