The Association Uric Acid and Adenosine Deaminase in Neuropsychiatric Disorders.

Dr. Santoshi R. Ghodake; Dr. Adinath N. Suryakar

Volume : VIII, Issue : VII, July - 2019

The Association Uric Acid and Adenosine Deaminase in Neuropsychiatric Disorders.

Dr. Santoshi R. Ghodake, Dr. Adinath N. Suryakar

Abstract :

Objectives: Oxidative stress and inflammation may be seen as both causes and consequences of cellular pathophysiology in many disorders, including neuropsychiatric disorders. Uric acid (UA) and adenosine deaminase (ADA) levels are associated Oxidative stress and inflammation. Methods: The study group included a total of 480 subjects of which 240 were healthy controls and 240 of patients (60 schizophrenia, 60 major depression and 60 Epilepsy and 60 Alzheimer�s disease. Results: Significant decreased in UA and significantly high MDA and ADA activity were found in all group patients when compared to controls. Significant negative correlations between the UA and ADA levels in all patient groups except epileptic patients (Group III). Conclusion: It is possible that low serum UA levels are not able to prevent the free radical toxicity, leading to the development of inflammatory reactions leading to tissues destruction due to oxidative stress.