The comparison of L–carnitine and amifostine in prevention of radiation induced cardiac injury

Kamuran Ibis; Murat Caloglu; Vuslat Yurut–Caloglu; Fulya Oz–Puyan; Armagan Altun; Gulden Angin; Fadime Alkaya; Rusen Cosar; Mert Saynak; Gulay Altun; Cem Uzal; Zafer Kocak

Volume : VII, Issue : III, March - 2018

The comparison of L–carnitine and amifostine in prevention of radiation induced cardiac injury

Kamuran Ibis, Murat Caloglu, Vuslat Yurut Caloglu, Fulya Oz Puyan, Armagan Altun, Gulden Angin, Fadime Alkaya, Rusen Cosar, Mert Saynak, Gulay Altun, Cem Uzal, Zafer Kocak

Abstract :

We aimed to compare the effects of amifostine (AMI) and L–carnitine (LC) in prevention of radiation induced cardiac injury. Sixty–four rats were divided into 6 groups: Control (CONT), radiotherapy (RT), AMI+RT, LC+RT, and LC. The animals in RT groups received 15 Gy/fraction by 6 MV photon, to the cardiac area. After 6 months follow–up, electrocardiograpy and histopatologic evaluation were carried out. Significant difference was found between AMI+RT and RT, LC+RT and RT, and LC+RT and CONT in terms of myocardial degeneration. Atrial fiosis was found to be significantly different between AMI+RT and RT. Significant difference was found between groups in terms of ventricular fiosis. LC and AMI obviously prevented the prolongation of JTa, JTac and QTc intervals after irradiation. The cardioprotective effect of AMI was superior to LC in terms of myocardial degeneration, atrial fiosis and ventricular fiosis.