The Effect Of Selected Steroidal And Non–Steroidal Contraceptive Pills On Changes In The Body And Organ Weights Of Wistar Female Albino Rats.

M.P.Chikhale

Volume : IV, Issue : IX, September - 2015

The Effect Of Selected Steroidal And Non–Steroidal Contraceptive Pills On Changes In The Body And Organ Weights Of Wistar Female Albino Rats.

M. P. Chikhale

Abstract :

<p>The effects of steroidal and non&ndash;steroidal contraceptive oral pill on changes in the body and organ weight were studied in wistar female albino rats for 30 days. The steroidal combined oral contraceptive pill ( norgestrel + ethinylestradiol ) was diluted to 0.14mg/ ml (Low Dose ) , 0.21 mg/ml (dose as per literature ), and 0.43 mg/ ml ( high dose ). The non&ndash;steroidal oral contraceptive pill (Centchroman) was diluted to 0.29 mg/ ml ( Low Dose ) , 0.43 mg/ml (dose as per literature ) and 0.87 mg/ml ( high dose) . In steroidal pill fed rats almost all the reproductive organs and related glands exhibited moderate to highly significant decrease in the respective organ weights. However, uterus, adrenal and thyroid gland showed significant increase in their weights. Similarly in non&ndash;steroidal pill fed rats there was highly significant decrease in the weight of fallopian tubes and further the adrenal and thyroid weights were also found to be increased significantly (p&lt;0.01).In the present investigation a dose of 0.14mg/ml/rat/day has resulted into 49.14% increases in uterine weight however, dose of 0.29mg/ml/day/rat has resulted into 20.76% decline in uterine weight. The rate of gain in the body weight was decreased in all the groups treated with norgestrel + ethinylestradiol as well as Centchroman indicating some adverse effects on the rats. More research is needed to calculate the perfect dose which will not lead to any adverse effect.</p>