The Impact of Concomitant  administration of Antiarrhythmic agent  (Amiodarone) with Mustard oil on thyroid  gland in Experimental Animals

Doa’a Anwar Ibrahim

Volume : II, Issue : VIII, August - 2013

The Impact of Concomitant administration of Antiarrhythmic agent (Amiodarone) with Mustard oil on thyroid gland in Experimental Animals

Doa A Anwar Ibrahim

Abstract :

Natural herb products are used widely in different societies, as they had been used since the Ancient age. Mustard seeds are the small round seeds of various mustard plants, which is a cruciferous vegetable related to occoli, Brussels sprouts and cabbage. There are three principal types used to make mustard seeds: black mustard (Brassica nigra), white mustard (Brassica alba) and own mustard (Brassica juncea). Like other Brassicas, mustard seeds contain plentiful amounts of phytonutrients called glucosinolates, so used form many diseases like cancer and inflammation.On the other hand, amiodarone hydrochloride (2-butyl-3-benzofuranyl 4-(2-diethylaminoethoxy)-3,5-di-iodophenyl ketone hydrochloride ). It is a Class III antiarrhythmic agent prolonging the action potential duration and hence refractory period of atrial, nodal and ventricular tissues, thereby giving a very oad spectrum of activity. An increase in the refractory period of the atrial cells is a major contributing action to the control of atrial tachyarrhythmias. Aim of the work: This study is aimed to assess the possible goitergentic of amiodarone and mustard oil if they are given together by measuring thyroid function tests including (TSH, T3 and T4), weight of thyroid gland. Heart enzyme CK and the weight of the heart as well as ECG readings, in addition, the liver function enzymes (SGOT and SGPT) all these will be measured. Materials and methods: 30 adult male rabbits (weight range 1250-2000 g and age-9-12 months) were divided randomly to four groups each contain 8 animals except control group contains 6 animals. Second, third and fourth groups were given mustard oil (2g/d), amiodarome (8mg/kg) and combined (mustard oil 2g/d + amiodarome 8mg/kg) intragastric therapy respectively for 2 weeks. First group was kept as control. Results: Combination of mustard oil and amiodarone was shown significant increase in thyroid hormones (T3 and T4). This effect was supported by significant increased in the thyroid gland weight and reduction in body weight. In addition, mustard oil in combination form was reduced the liver function enzyme especially SGOT. Conclusion: from this study we approved that mustard oil may increase the goiterogenic effect of amiodarone if they are administered concomitantly for long time. On the other hand this oil has hepato- and cardioprotective effect and can ameliorate the toxic effects of amiodarone on liver and heart.