Volume : IX, Issue : VI, June - 2020

The incidence of CLABSI (Central Line Associated Blood Stream Infections) in a tertiary care centre- its etiological profile, antibiotic sensitivity and resistance pattern.

Dr. Gowri Veligandla, Rahul

Abstract :

Central Line Associated Blood Stream Infections –CLABSI are a leading cause of Hospital Acquired Infections and are associated with significant morbidity, mortality and healthcare expenditure. The objectives of this study were to determine the incidence of CLABSI, the etiological spectrum of microorganisms causing these infections and their antibiotic susceptibility patterns. This study included a total of 18 patients on Central lines. These patients were monitored daily for the development of HAI. The blood and catheter tip samples were collected from them after removal of Central line, which was done either on completion of treatment or after the development of sepsis. The samples were cultured to isolate the pathogens. Maki’s Roll Plate method was used for Catheter tip culture. The pathogens isolated from both the cultures of each case were tested against antibiotics using Kirby–Bauer disk diffusion method (CLSI guidelines, 2018) to determine their antibiotic susceptibility patterns. A diagnosis of CLABSI was made, when both catheter tip culture and blood culture yielded the same microorganism. If a case of CLABSI was identified, then antibiograms were compared to check whether it was Laboratory confirmed CLABSI or Probable CLABSI. The incidence of CLABSI was measured per 1000 central line days. In this prospective observational study, 3 cases of CLABSI (%CLABSI= 16.66%) were identified and all were Laboratory confirmed cases of CLABSI. This gave a significant CLABSI rate of 2.23 per 1000 central line days. The CLABSI causing pathogens identified in this study were Pseudomonas aeruginosa and Klebsiella pneumoniae. There were 2 cases (11.11%) of Blood Stream Infections (BSI) with no evidence of catheter colonization. These BSI cases were caused by pathogens like Escherichia coli and Klebsiella pneumoniae. There were 11 cases (61.11%) of asymptomatic catheter colonization caused by Coagulase–negative Staphylococci, where there were no evidences of BSI. The antibiotic susceptibility patterns of the isolates revealed a high incidence of resistance against conventional antibiotics like Ampicillin, Amoxicillin–clavulanate and Penicillin G. Hence, this study highlights the need for regular surveillance, periodic auditing of Infection Control Practices, and an effective antibiotic policy to tackle the problem of CLABSI .

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Article: Download PDF    DOI : 10.36106/ijsr  

Cite This Article:

THE INCIDENCE OF CLABSI (CENTRAL LINE ASSOCIATED BLOOD STREAM INFECTIONS) IN A TERTIARY CARE CENTRE- ITS ETIOLOGICAL PROFILE, ANTIBIOTIC SENSITIVITY AND RESISTANCE PATTERN., Dr. Gowri Veligandla, Rahul INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-6 | June-2020

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