Volume : VII, Issue : XI, November - 2018

The role of oxidative stress and antioxidative status as screening test for alcoholic liver disease

Nisha Chauhan, Dr Busi Karunanand, Dr D K Sharma, Dr Sanjiv Kumar Bansal, Dr Arpita Suri, Dr Shikhaa Mahajan

Abstract :

 

Background– The prevalence of Alcoholic Liver Disease (ALD) has increased in the developing countries including India. Alcohol consumption is associated with production of reactive oxygen species, lower cellular antioxidant levels and enhance oxidative stress in many tissues especially the liver. Therefore our study focusses on markers of oxidative stress which may have a role in etiopathogenesis of ALD and also their correlation with conventional markers of liver functioning.

Material and methods– 50 patients of alcohol liver disease, fulfilling the inclusion criteria, were enrolled for the study after taking written and informed consent as cases and 50 age and gender matched healthy individuals as controls from general population. Serum AST (SGOT), ALT (SGPT), ALP and Total protein were estimated by enzymatic methods on auto–analyzer EM–200(erba) and Plasma Superoxide dismutase (SOD), Malondialdehyde (MDA) were measured by ELISA.

 

Results– The mean age of the study population was found to be 53.2 ± 3.81 (cases) and 52.92 ± 2.73 (controls).The levels of AST,ALT,AST/ALT ratio, ALP, Malondialdehyde, Superoxide dismutase were statistically  higher whereas the levels of  serum total proteins were statistically lower in cases as compared to controls.The Pearson correlation between serum Total Proteins and Malondialdehyde was found to be statistically significant(r=0.445).

 

Conclusions– According to our study, excessive alcohol intake increases the hepatic oxidative stress. The measurement of these markers of antioxidant depletion (GSH) and hepatic damage (MDA) may be used as screening test for risk assessment in ALD patients.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

The role of oxidative stress and antioxidative status as screening test for alcoholic liver disease , Nisha Chauhan, Dr Busi Karunanand, Dr D K Sharma, Dr Sanjiv Kumar Bansal, Dr Arpita Suri, Dr Shikhaa Mahajan , INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7|Issue-11| November-2018

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