Volume : VII, Issue : II, February - 2018
THE STUDY OF EFFECT OF CANAGLIFLOZIN ON POST–PRANDIAL HYPERGLYCEMIA IN TYPE 2 DIABETES MELLITUS
Surya Prakasa Rao Salla, Shalini Penikilapate, Mrudula Besetty, Savitri Aninditha Nandula, Degala Yamini Venkata Sravya
Abstract :
BACKGROUND
Diabetes MellituS, now a leading cause of morbidity and mortality for the forseeable future.
Pathophysiological features:
1) Impaired insulin secretion
2) Peripheral insulin resistance
3) Excessive hepatic glucose production
Clinically these patients demonstrate virtually absent first phase of insulin and c peptide response to iv glucose, a reduced second phase response and marked flattening of glucose insulin secretion dose response curve.
This study on Gliflozins mainly work on sodium glucose cotransporter 2 inhibitors which block the reabsorption of glucose system in the kidney. This significantly lowers HbA1C level in severe hyperglycemic type 2 diabetes mellitus patients.
Aims and Objectives : To study the effect of canagliflozin on post prandial plasma glucose in Type2 diabetes mellitus patients mostly eating parboiled rice.
MATERIALS AND METHODS
84 patients of type2 diabetes mellitus of >15 yrs of age having elevated FPG/normal FPG but with increasing PPBG attended to NRI Institute of medical sciences, Sangivalasa, Visakhapatnam during the study period from 1st January 2017 to 31st December 2017.
RESULTS
This study included total of 84 cases of T2 DM and was designed to evaluate the effect on 2hr PPG level. Before canagliflozin therapy the mean PPG was 272.345mg/dl and after treatment with canagliflozin 200mg it was decreased by 50.77mg% (134.071mg/dl) at the end of 24 weeks.
CONCLUSION
From this study it is evident that
– Canagliflozin monotherapy is useful in early stages of T2 DM with elevated PPPG.
– Parboiled rice is the predominant staple diet in T2DM patients in Andra Pradesh, so prescribing Canagliflozin is very much convenient to control 2hr PPPG.
Keywords :
T2DM Type 2 Diabetes Mellitus FPG Fasting plasma glucose PPPG Post Prandial Plasma Glucose Canaglifiozin. Parboiled rice
Article:
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DOI : 10.36106/ijsr
Cite This Article:
Surya Prakasa Rao Salla, Shalini Penikilapate, Mrudula Besetty, Savitri Aninditha Nandula, Degala Yamini Venkata Sravya, THE STUDY OF EFFECT OF CANAGLIFLOZIN ON POST-PRANDIAL HYPERGLYCEMIA IN TYPE 2 DIABETES MELLITUS, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH :
Volume-7 | Issue-2 | February-2018
Number of Downloads : 279
References :
Surya Prakasa Rao Salla, Shalini Penikilapate, Mrudula Besetty, Savitri Aninditha Nandula, Degala Yamini Venkata Sravya, THE STUDY OF EFFECT OF CANAGLIFLOZIN ON POST-PRANDIAL HYPERGLYCEMIA IN TYPE 2 DIABETES MELLITUS, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-2 | February-2018
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