THE STUDY OF EFFECT OF CANAGLIFLOZIN ON POST–PRANDIAL HYPERGLYCEMIA IN TYPE 2 DIABETES MELLITUS

Surya Prakasa Rao Salla; Shalini Penikilapate; Mrudula Besetty; Savitri Aninditha Nandula; Degala Yamini Venkata Sravya

Volume : VII, Issue : II, February - 2018

THE STUDY OF EFFECT OF CANAGLIFLOZIN ON POST–PRANDIAL HYPERGLYCEMIA IN TYPE 2 DIABETES MELLITUS

Surya Prakasa Rao Salla, Shalini Penikilapate, Mrudula Besetty, Savitri Aninditha Nandula, Degala Yamini Venkata Sravya

Abstract :

BACKGROUND

Diabetes MellituS, now a leading cause of morbidity and mortality for the forseeable future.

Pathophysiological features:

1) Impaired insulin secretion

2) Peripheral insulin resistance

3) Excessive hepatic glucose production

Clinically these patients demonstrate virtually absent first phase of insulin and c peptide response to iv glucose, a reduced second phase response and marked flattening of glucose insulin secretion dose response curve.

This study on Gliflozins mainly work on sodium glucose cotransporter 2 inhibitors which block the reabsorption of glucose system in the kidney. This significantly lowers HbA1C level in severe hyperglycemic type 2 diabetes mellitus patients.

Aims and Objectives : To study the effect of canagliflozin on post prandial plasma glucose in Type2 diabetes mellitus patients mostly eating parboiled rice.

MATERIALS AND METHODS

84 patients of type2 diabetes mellitus of >15 yrs of age having elevated FPG/normal FPG but with increasing PPBG attended to NRI Institute of medical sciences, Sangivalasa, Visakhapatnam during the study period from 1^st January 2017 to 31^st December 2017.

RESULTS

This study included total of 84 cases of T2 DM and was designed to evaluate the effect on 2hr PPG level. Before canagliflozin therapy the mean PPG was 272.345mg/dl and after treatment with canagliflozin 200mg it was decreased by 50.77mg% (134.071mg/dl) at the end of 24 weeks.

CONCLUSION

From this study it is evident that

– Canagliflozin monotherapy is useful in early stages of T₂DM with elevated PPPG.

– Parboiled rice is the predominant staple diet in T2DM patients in Andra Pradesh, so prescribing Canagliflozin is very much convenient to control 2hr PPPG.