Therapeutic Effect of Aqueous Extract of Vitis  Vinifera L. Against Thyrotoxicosis Induced by  Levothyroxine Sodium in Rabbit Females

Taghreed U.Muhammd

Volume : II, Issue : X, October - 2013

Therapeutic Effect of Aqueous Extract of Vitis Vinifera L. Against Thyrotoxicosis Induced by Levothyroxine Sodium in Rabbit Females

Taghreed U. Muhammd

Abstract :

To investigat the hepatoprotective potential of aqueous grape leaf extract on levothyroxine sodium induced liver toxicity in femals of rabbit. Liver injury was induced by levothyroxine sodium (5 �g) on the first day of experiment. Vitis vinifera L.leaf extract (100mg/ml) was administered orally daily for two months. The animals were sacrificed after two months and the hepatoprotective activity was assessed by using various biochemical parameters. In levothyroxine sodium treated femals of rabbit , the lactate dehydrogenase(LDH), acid phosphatase (ACP), and alkaline phosphatase (ALP) levels were significantly increased. The Vitis vinifera L.leaf extract administration therapy the toxic effect of levothyroxine sodium on the LDH, ACP, and ALP.