To evaluate and compare the effects of two different  doses of clonidine (0.5 and 1 �g/kg bw) as an adjuvant  to 15 mg hyperbaric bupivacaine in patients undergoing  lower abdominal surgeries under spinal anesthesia

Dr. Upasna Bhatia; Dr. Mikita J Chaudhari; Dr. Sumit Parmar; Dr. Kirti D Patel

Volume : II, Issue : VII, July - 2013

To evaluate and compare the effects of two different doses of clonidine (0.5 and 1 �g/kg bw) as an adjuvant to 15 mg hyperbaric bupivacaine in patients undergoing lower abdominal surgeries under spinal anesthesia

Dr. Upasna Bhatia, Dr. Mikita J Chaudhari, Dr. Sumit Parmar, Dr. Kirti D Patel

Abstract :

Clonidine is added to intrathecal Bupivacaine to improve intraoperative analgesia and to increase the duration of sensory and motor block. This is study of 60 patients of either sex of ASA I & II status undergoing lower abdominal surgeries . They were randomly divided into three groups of 20 each. Group A patients received Bupivacaine heavy 0.5% 15mg + Clonidine 0.5 �g/kg Group B received Bupivacaine heavy 0.5% 15mg + Clonidine 1 �g/kg and Group C received Bupivacaine heavy 0.5% 15 mg. . Intrathecal clonidine 0.5�g/kg and 1 �g/kg delayed the onset of sensory blockade by 197.8(+/-20.2)sec and 225.8(+/-22.1)sec respectively when compared to control group 179.8(+/- 17.01)sec. Similarly onset of motor blockade was also delayed by 257.3(+/-26.6) sec in Group A, 288 (+/-24.3)sec in Group B and 222.3(+/-20.03)sec in Group C. there was statistically significant (P<0.05) decrease in mean pulse rate intraoperatively from 30 min upto 2 hours. Fall in blood pressure was slightly greater in clonidine group (P<0.001) but was not severe. Duration of post operative analgesia was very prolonged in group B:370(+/-39.95)min and group A:335(+/-33.32)min compared to group C: 235.5(+/-18.84)min which was highly significant. Adding clonidine 1 �g/kgbw to intrathecal Bupivacaine prolongs the duration of spinal anesthesia and postoperative analgesia without severe adverse effects