To Evaluate the Activity of Glycyrrhiza  Glabra Linn and Vanda Roxburghi in  Animal Model of Arthritis

Dr Arvind Kumar Gupta; Dr Vinod Bharadwaj; Dr Suman Lata; Dr Rajeev Sharma; Dr Sundeep Kacker; Arun Kumar Sharma

Volume : II, Issue : V, May - 2013

To Evaluate the Activity of Glycyrrhiza Glabra Linn and Vanda Roxburghi in Animal Model of Arthritis

Dr Arvind Kumar Gupta, Dr Vinod Bharadwaj, Dr Suman Lata, Dr Rajeev Sharma, Dr Sundeep Kacker, Arun Kumar Sharma

Abstract :

Introduction: Arthritis a �great cripler �and exact etiopathology is not clear, inflammatory reaction underly the genesis of rheumatoid arthritis. Presently prolonged therapy with steroids and NSAIDs associated with number of adverse effect. Since ancient time indigenous plants are being used for arthritis, but not properly screened and evaluated. Therefore we planned to study of these indigenous plants i.e. Glycyrrhiza glaa linn (G.Glaa) and Vanda roxburghi (V.roxburghi). Study design: A prospective study was designed for acute, subacute and chronic inflammatory arthritis and anti–pyretic models were produced in albino rats. They were treated orally with graded doses of these drugs and their outcomes were observed and compared with standard drugs i. e. phenylbutazone and aspirin. Statistical analysis was performed by student�s �t� test and �P� value was calculated referring to the appropriate table.. Results: LD50 was found 2399 mg for both the herbs on oral administration. Both the drugs in a dose of 400 mg/kg, were found to be significant (p