Volume : V, Issue : VI, June - 2016

To Study AntidepressantLike Activity of Escitalopram oxalate in Rats.

Dhara M. Jadav

Abstract :

 Depression is a multifactorial disease, commonly occurring due to deficit of norepinephrine, dopamine and serotonin. Escitalopram oxalate, inhibits the CNS neuronal uptake of serotonin, is used in treatment of depression. Imipramine inhibits the reuptake of norepinephrine , Fluoxetine inhibits the reuptake of serotonin in the synaptic cleft and selegeline inhibits the reuptake of dopamine. This study was done to explore the antidepressant activity of Escitalopram in combination with Fluoxetine, Imipramine, Selegeline in rats by forced swim test. 54 rats were grouped randomly, of 6 rats in each group. Twenty four hours following the pretest session, they were given distilled water, escitalopram (5 mg/kg, 10mg/kg) and then combination of all antidepressants together (5 mg/kg, 10mg/kg) intraperitoneally. After 30 minutes of drug administration, they were made to swim individually in the cylindrical transparent jar with a water column of 30 cm for 6 minutes. Escitalopram in combination with (Fluoxetine, Imipramine, Selegeline) showed significant (p value <0.05) reduction in immobility time with increase in dosage. Escitalopram + Fluoxetine (10mg/kg) showed significant antidepressant activity compared to escitalopram with other antidepressants. Escitalopram+( Fluoxetine,Imipramine, Selegeline) together could be helpful in patients with depression.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dhara M. Jadav To Study AntidepressantLike Activity of Escitalopram oxalate in Rats. International Journal of Scientific Research,Vol : 5, Issue : 6 JUNE 2016

Number of Downloads : 712

References :